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BioSignal
Peptide (Research Chemical)Reviewed July 2026 · v1.0

CJC-1295

Long-acting GHRH Analog (research chemical)

A single human study shows CJC-1295 raises GH/IGF-1, but there are no trials of any clinical or body-composition outcome, so benefit is ungraded and safety is unknown.

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BioSignal's confidenceLimited evidenceEvidence maturityExperimentalProven in humans4/9 steps · Partly establishedSafetyCaution

How confident is BioSignal?

Our overall position, and how sure we are of it across each dimension — including where we are not sure at all.

Limited evidence

A single human study shows CJC-1295 raises GH/IGF-1, but there are no trials of any clinical or body-composition outcome, so benefit is ungraded and safety is unknown.

Early or sparse human evidence; conclusions remain uncertain.

Human Evidence

Limited evidence

One human PK/PD study (raises GH/IGF-1); no outcome/efficacy trials.

Mechanistic Plausibility

Moderate confidence

Clear GHRH-analog pharmacology; raising GH/IGF-1 is real.

Research Activity

Low

Minimal; no active outcome program.

Safety Profile

Caution

No outcome-level human safety data; unregulated product; GH/IGF-1 elevation carries risk.

Consensus

Limited evidence

Not approved; no guideline status.

Where the evidence stands today

How mature the science is, what kinds of evidence exist, and — the part nobody else prints — what is still missing.

4/9

steps proven in humans

Partly established

4 steps not demonstrated: Small human outcome trials · Large human RCTs · Clinical outcomes · Guideline / regulatory support

  1. Guideline / regulatory support

    Not shown

    Not approved.

  2. Clinical outcomes

    Not shown

    None.

  3. Large human RCTs

    Not shown

    None.

  4. Small human outcome trials

    Not shown

    No clinical/body-composition outcome trials.

  5. Human safety data

    Limited

    Short-term pharmacology only.

  6. Human biomarker / pharmacology

    Proven

    One study: raises GH/IGF-1.

  7. Animal

    Proven

    Preclinical.

  8. Cell / in vitro

    Proven

    Receptor pharmacology.

  9. Mechanistic plausibility

    Proven

    GHRH-analog pharmacology.

The bottom line

What we know, what we think, what we don't know — and what would change our mind.

It raises GH/IGF-1

In a human study, CJC-1295 produced prolonged elevation of GH and IGF-1. That is the extent of the human evidence.

Hormone ≠ benefit

Elevating GH/IGF-1 is often assumed to build muscle and aid recovery, but that benefit is unproven in humans — and GH trials in healthy older adults showed more side effects than benefit.

Everything clinical

Whether it improves any real outcome, safe dose, long-term safety, and product quality are all unknown.

Little rigorous research

Mostly off-label / anecdotal use; no active outcome program.

What would change the picture

A human outcome trial (body composition, function, or safety) would allow the first graded efficacy claim.

The biggest myth

“CJC-1295 builds muscle / burns fat / improves recovery in people.”

Not establishedLimited evidence

No human outcome trials support any body-composition or performance benefit.

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Still have a question about cjc-1295?

Answers are retrieved from this record and the rest of the knowledge graph — never generated.

Ask about CJC-1295

Why people take cjc-1295

Popularity is not evidence — but it is not stupid either. This explains the interest on its own terms.

People search CJC-1295 for muscle gain, recovery, and anti-aging via growth-hormone elevation. Interest is not evidence: it does raise GH/IGF-1, but there are no human outcome trials, raising GH/IGF-1 is not proven beneficial in healthy adults, and it is prohibited in sport.

If you're here because…

Jump straight to the part of the evidence that answers your question.

“Does it actually work?”Does it work?“Is it safe / legal?”Is it safe?“How does it connect to the GH axis?”Connected science

Approval, safety and regulatory

What it is approved for, who should be careful, what remains unknown — and the limits of what this evidence can tell you.

Regulatory status

Not Approved

Availability

Unapproved research chemical

Sport (WADA)

Prohibited (GHRH analog, S2.2) — confirm at publication

Known safety profile

Unknown at the outcome level; short studies note GH/IGF-1 elevation, injection-site reactions, water retention, possible glucose effects.

Common issues

  • Injection-site reactions
  • Fluid retention
  • Possible glucose effects

Use caution if

  • Everyone (unstudied)
  • Cancer history
  • Diabetes
  • Pregnancy

Long-term unknowns

No long-term human safety data.

Limits of this evidence

Human evidence is a single pharmacology study; no outcome or long-term safety data.

Full regulatory and sport detail
Regulatory approval
None.
Approved indication
None.
Investigational
No active outcome program.
Research chemical
Yes — sold as a research chemical.
Compounding
Not established as an approved compounding substance.
Sport (WADA)
GHRH analogs are prohibited (S2.2) — confirm at publication.
Publication note
Re-confirm regulatory and anti-doping status against primary sources at publication.

Demand, separated from evidence

Every claim people make about this, counted against what the evidence actually showed.

BioSignal evaluated 4 popular claims about cjc-1295.

Here is where each one landed — including the claims of harm, where “not established” is reassuring rather than damning.

Supported by evidence
1
Not established
3

Popularity is not evidence. This is simply a count of every claim BioSignal evaluated on this page, sorted by what the evidence actually showed — the full reasoning behind each verdict is in the Evidence Review below.

Supported by evidence

  • CJC-1295 raises GH and IGF-1.

Not established

  • CJC-1295 builds muscle / burns fat / improves recovery in people.
  • Raising GH/IGF-1 is inherently good.
  • CJC-1295 is safe / approved / legal.

The evidence review

Every claim with the reasoning behind its verdict, the doses actually studied, where scientists agree and disagree, and the questions still open.

What people claim

Every popular claim, with BioSignal’s verdict and how confident we are in it. The verdicts are always visible; open any claim to read the evidence behind it.

CJC-1295 raises GH and IGF-1.SupportedLimited evidence

A human pharmacology study shows sustained GH/IGF-1 elevation.

Raising GH/IGF-1 is inherently good.Not establishedModerate confidence

Higher GH/IGF-1 is not proven beneficial in healthy adults and may carry metabolic and neoplastic risk.

CJC-1295 is safe / approved / legal.Not establishedModerate confidence

Not FDA-approved; unregulated research chemical; prohibited in sport (GHRH analogs, WADA S2).

Doses used in human studies

What was actually given to participants in the research. These are descriptions of studies, not recommendations.

Healthy adults

Intervention
CJC-1295 SC (single/repeat)
Dose
pharmacology doses (µg/kg)
Duration
days–weeks
Outcome
GH/IGF-1 levels (not a clinical outcome)
Notes
Only human data are hormone levels; no evidence-based therapeutic dose.

Where scientists agree — and don’t

Agreed

  • It raises GH/IGF-1 (pharmacology)

Debated

  • Whether raising GH/IGF-1 helps healthy adults at all
  • How it compares to approved GHRH analogs

Unknown

  • Every clinical outcome and long-term safety question

What remains unknown

  • Does it improve any human clinical or body-composition outcome?
  • What is a safe dose and the long-term safety?
  • What is the product identity/purity in unregulated supply?

Questions people actually ask

Does CJC-1295 build muscle?

There is no human evidence that it does. It raises growth hormone and IGF-1 in one study, but no trial has shown that this translates into muscle, fat loss, or recovery benefits — and raising these hormones is not proven beneficial in healthy adults.

Is CJC-1295 legal?

It is not an approved medication; it is sold as an unregulated research chemical and is prohibited in sport.

Practical takeaways

  • CJC-1295 raises GH/IGF-1 — but that is a lab value, not a proven benefit.
  • There are no human outcome trials; body-composition and recovery claims are unproven.
  • Raising GH/IGF-1 is not established as beneficial in healthy adults.
  • It is unapproved, unregulated, and banned in sport.
  • For muscle and recovery, the proven levers are training, protein, and sleep — not a GH secretagogue.

How it works

The mechanism comes last on purpose. A compelling explanation of how something might work is the easiest part of the story to tell, and the part most likely to outlive the evidence for it.

How we found out

  1. 2006 — Teichman (JCEM)

    Sustained GH/IGF-1 elevation in healthy adults.

  2. Since

    No human outcome trials; no approval.

References

Verified sources. BioSignal does not print a citation it has not checked.

  1. 01

    Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

    J Clin Endocrinol Metab 91(3):799-805 · 2006

Version history

  • 1.0

    Initial review-hardened record (Experimental; Insufficient/Caution). Review cadence: Annual.

Continue exploring

Three places this record leads next.

Signal RecordTesamorelinEvidence anchorOpenBiomarkerIGF-1The downstream marker of growth-hormone activityOpenFoundationHealthy AgingMixed EvidenceOpen
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