GGT

Gamma-glutamyl transferase (GGT) is an enzyme found in the liver and bile ducts. It is a sensitive — but non-specific — marker of liver and biliary stress, and it also tracks with oxidative stress and cardiometabolic risk.

GGT helps interpret other liver tests (a raised ALP with a raised GGT points to a liver/biliary source) and flags alcohol-related and fatty-liver injury. Elevated GGT is also independently associated with cardiovascular and metabolic risk.

1. 1

   FoundationMetabolic HealthThe best place to understand the major drivers of metabolic disease.
2. 2

   ConditionMASLD / MASHMetabolic fatty liver disease
3. 3

   Signal RecordSemaglutideGLP-1 Receptor Agonist
4. 4

   Body SystemDigestiveGut health, the microbiome, and nutrient absorption.
5. 5

   BiomarkerALTThe most liver-specific enzyme

1. Measure it
2. Understand your result
3. See what raises and lowers it
4. Apply evidence-based interventions
5. Recheck on your review cadence

An orientation to how this topic is typically approached — not medical advice.

A raised GGT most often reflects fatty liver or alcohol, and it confirms that an elevated alkaline phosphatase is of liver/biliary origin. Persistently high GGT warrants looking for a cause and attending to cardiometabolic risk.

• Part of an extended liver panel
• Interpreted with ALT, AST, and ALP

GGT is a validated, sensitive but non-specific marker of hepatobiliary stress; its association with cardiometabolic risk is well described, though it is used as a marker, not a target.

• ACG / AASLD guidance on interpreting liver chemistries

Sources are named authoritative guidelines and scientific bodies. Biomarker pages present established clinical context; calibrated evidence verdicts on specific interventions live in the linked Signal Records.